Fanapt® dosing and titration

A dose range of 6 to 12 mg twice daily was efficacious for most patients1
  • The maximum recommended dose is 12 mg twice daily (24 mg/day) taken without regard to meals
Fanapt® titration may help patients achieve an efficacious dose in as few as 4 days1

 

Titration pack for therapy initiation

Fanapt® must be titrated from a low starting dose to avoid orthostatic hypotension1
  • Control of symptoms may be delayed during the first 1 to 2 weeks of therapy
  • Maximum daily dose adjustments of 2 mg twice daily (4 mg/day)
  • Slow titration of Fanapt® (iloperidone) may reduce dizziness, tachycardia, and syncope, which are associated with orthostatic hypotension

 

Consider metabolic pathways

In certain circumstances, Fanapt® dose should be reduced by one-half1
  • When patients are poor metabolizers of CYP2D6
  • When administered concomitantly with strong CYP2D6 or CYP3A4 inhibitors
    • When the CYP2D6 or CYP3A4 inhibitors are withdrawn from the combination therapy, Fanapt® dose should be increased to where it was before
QT prolongation was augmented by the presence of CYP2D6 or CYP3A4 inhibition1
  • The use of Fanapt® should be avoided in combination with drugs known to prolong QTc and in patients with histories of significant cardiovascular illness
Fanapt® significantly improved overall schizophrenia symptoms.1,2
Find out more
References: 1. Fanapt [package insert]. Washington, DC: Vanda Pharmaceuticals, Inc.: 2016. 2. Cutler AJ, Kalahi AH, Weiden PJ, Hamilton J, Wolfgang CD. Four-week, double-blind, placebo- and ziprasidone-controlled trial of iloperidone in patients with acute exacerbations of schizophrenia. J Clin Psychopharmacol. 2008;28(2 Suppl 1):S20-S28.